Advanced Analysis in Steel Frame Design presents formal guidelines for the use of second-order inelastic analysis in the design and assessment of steel framing systems. This advanced analysis methodology focuses on the strength of the structural system as a whole, rather than design load levels producing first member failure. The report includes design rules, background and commentary regarding these rules, and benchmarks for columns and frames. It also provides specific recommendations regarding the rigor of the analysis, minimum modeling requirements, consideration of limit states, serviceability, and live load reduction, yet allows latitude for the judgment of the design engineer.